# REGULATION OF MICROBIAL NITROGEN METABOLISM

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1990 · $179,185

## Abstract

The genes for Histidine UTilization (hut) in Klebsiella aerogenes are
typical of a large number of genes whose expression is strictly regulated
by the available supply of nitrogen.  Thus nitrogen regulation of hut
serves as a model system for this kind of pleiotropic control.  The goal of
the research proposed here is to develop an in vitro transcription system
for the hut operon of K. aerogenes that is responsive to regulation by the
nitrogen regulatory factor(s) and to study the molecular basis for that
regulation.  The specific objectives of the five-year proposal period are:

(1) To determine the mechanism of carbon regulation at the promoter of the
hutUH operon, (2) To begin an analysis of the nitrogen regulation at the
promoter of the hutUH operon, and (3) To extend our understanding of the
hut operons themselves.

## Key facts

- **NIH application ID:** 3126445
- **Project number:** 5R01AI015822-11
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** ROBERT A BENDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $179,185
- **Award type:** 5
- **Project period:** 1979-05-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126445

## Citation

> US National Institutes of Health, RePORTER application 3126445, REGULATION OF MICROBIAL NITROGEN METABOLISM (5R01AI015822-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126445. Licensed CC0.

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