# PAUCICLONAL IMMUNITY:  MODELS FOR DIVERSIFICATION

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 1987 · $178,697

## Abstract

This is a grant application to continue our studies of antibodies to the simple
antigenic determinants phosphocholine (PC), group A streptococcal carbohydrate
(GAC) and alpha (1 yields 3) dextran.  Our goal in these studies is to provide
evidence of how antibody diversity is generated.  In particular, in the present
proposal we address questions about how diverse antibodies really are and
whether evolutionary relationships are preserved among antibodies with similar
specificity.  In addition, we will examine questions concerning combinatorial
diversity generated by heavy-light chain pairing and whether VH genes pair
randomly with all CH genes.  Finally, we will probe the relationship of VH
region expression and L chain expression.

## Key facts

- **NIH application ID:** 3126485
- **Project number:** 5R01AI015926-08
- **Recipient organization:** WASHINGTON UNIVERSITY
- **SAM.gov UEI:** L6NFUM28LQM5
- **Principal Investigator:** SAMUEL L. STANLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $178,697
- **Award type:** 5
- **Project period:** 1979-08-01 → 1989-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126485

## Citation

> US National Institutes of Health, RePORTER application 3126485, PAUCICLONAL IMMUNITY:  MODELS FOR DIVERSIFICATION (5R01AI015926-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126485. Licensed CC0.

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