# EPIDEMIOLOGY OF CHLAMYDIA TRACHOMATIS INFECTIONS

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1987 · $222,927

## Abstract

This project is designed to increase knowledge of the epidemiology of human
Chlamydia trachomatis infections.  The etiological role of these organisms in
trachoma, non gonorrheal urethritis (of the male), inclusion conjunctivitis of
the newborn, and pneumonitis of infancy has been established and much has been
learned about the epidemiology of C.  trachomatis infections of the eye, the
genital tract, and newborns in both trachoma endemic and nonendemic areas of the
world.  Evidence regarding the disease significance of C. trachomatis infections
of the female genital tract (cervicitis, salpingitis, peritonitis and
perihepatitis) has been accumulating and studies of these infections are
proposed.  Although no etiological significance has yet been demonstrated, the
organisms have been isolated from the middle ear, pharynx and the rectum.  We
have serologic epidemiological data from U.S. population groups strongly
suggesting that these organisms cause more frequent infection than can be
accounted for by known eye and genital tract disease.  Our serological data
suggests that C.  trachomatis is etiologically associated with pneumonia of
children after infancy and in adults.  A series of studies of the role of C.
trachomatis in pneumonia and acute lower respiratory disease are proposed.  In
addition we plan to utilize our unique specific serological test (micro
immunofluorescence) for both serum and local secretions in preliminary studies
of various disease syndromes potentially associated with C. trachomatis (acute
respiratory disease, chronic obstructive pulmonary diseases, sinusitis, otitis,
ideopathic inflammation of the bowel) to identify targets for some specific
etiological and epidemiological studies.  Patients with compromised pulmonary
(e.g. cystic fibrosis) or immunological systems will be studied to determine the
potential role of C. trachomatis in their disease process.  Also, couples with
infertility problems will be similarly investigated.

## Key facts

- **NIH application ID:** 3126600
- **Project number:** 3R01AI016222-08S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** J T GRAYSTON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $222,927
- **Award type:** 3
- **Project period:** 1979-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126600

## Citation

> US National Institutes of Health, RePORTER application 3126600, EPIDEMIOLOGY OF CHLAMYDIA TRACHOMATIS INFECTIONS (3R01AI016222-08S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126600. Licensed CC0.

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