# CLONING OF INFLUENZA VIRAL RNA SEGMENTS

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1987 · $193,685

## Abstract

Influenza is a major human disease without any effective prophylaxis or
therapy.  Every year influenza inflicts enormous human suffering in the
form of increased morbidity and mortality.  In addition, a staggering
economic loss (nearly 4 billion dollars in the USA alone) is attributed
directly to influenza.  The goal of this project is to elucidate the
property of this virus and its behavior at the genomic level and to
investigate towards developing a better immunogen for prophylaxis.
Therefore, we plan to continue studying influenza genes using recombinant
DNA cloning technology and elucidate the primary and secondary structure of
viral proteins.  Furthermore, we plan to continue expressing the cloned
DNAs using appropriate vectors in mammalian cells.  We also want to make
specific changes at the desired location, determine precisely the function
of each domain of the viral proteins and elucidate the structure-function
relationship.  In addition, we want to express hemagglutinin and
neuraminidase genes in yeast and explore newer ways to make a better
subunit vaccine.

## Key facts

- **NIH application ID:** 3126632
- **Project number:** 5R01AI016348-08
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** DEBI P. NAYAK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $193,685
- **Award type:** 5
- **Project period:** 1980-05-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126632

## Citation

> US National Institutes of Health, RePORTER application 3126632, CLONING OF INFLUENZA VIRAL RNA SEGMENTS (5R01AI016348-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126632. Licensed CC0.

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