# THE EOSINOPHIL PEROXIDASE SYSTEM

> **NIH NIH R01** · TUFTS MEDICAL CENTER · 1987 · $154,657

## Abstract

The objective of the research is to characterize the eosinophil peroxidase
system which consists of the granular enzyme eosinophil peroxidase, the cellular
product hydrogen peroxide, and an oxidizable co-factor, supplied as iodide.  An
active peroxidase system has been identified in human and guinea pig peritoneal
exudate eosinophils.  Methods for measurement of hydrogen peroxide production by
eosinophils have been developed.  Anaerobic studies have shown that the
peroxidase system does not participate in eosinophil - mediated damage of
schistosomula.  Further studies will explore hydrogen peroxide production, as
well as functions of the peroxidase system.

## Key facts

- **NIH application ID:** 3126653
- **Project number:** 7R01AI016432-08
- **Recipient organization:** TUFTS MEDICAL CENTER
- **SAM.gov UEI:** MY2ERHGDV956
- **Principal Investigator:** STEPHANIE H PINCUS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $154,657
- **Award type:** 7
- **Project period:** 1987-06-01 → 1988-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126653

## Citation

> US National Institutes of Health, RePORTER application 3126653, THE EOSINOPHIL PEROXIDASE SYSTEM (7R01AI016432-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126653. Licensed CC0.

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