# THE GENETIC CONTROL OF VIRULENCE IN GROUP A STREPTOCOCCI

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 1987 · $115,588

## Abstract

This project will attempt to elucidate the molecular basis for natural variation
in resistance to phagocytosis by virulent group A Streptococci.  Employing
genetic and biochemical techniques the role of bacteriophage and chromosomal
genes in the regulation of M protein synthesis will be investigated.
Experimental data will further evaluate preliminary evidence that lysogenic
conversion imparts resistance to phagocytosis.  Comparison of restriction
endonuclease maps of Bacteriophage DNA will extend our understanding of
interactions between the virus and bacteria which result in resistance to
phagocytosis.

## Key facts

- **NIH application ID:** 3126788
- **Project number:** 5R01AI016722-07
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **SAM.gov UEI:** KABJZBBJ4B54
- **Principal Investigator:** PAUL Patrick CLEARY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $115,588
- **Award type:** 5
- **Project period:** 1981-09-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126788

## Citation

> US National Institutes of Health, RePORTER application 3126788, THE GENETIC CONTROL OF VIRULENCE IN GROUP A STREPTOCOCCI (5R01AI016722-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126788. Licensed CC0.

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