# GENETICS OF RESISTANCE TO TRICHINELLA SPIRALIS

> **NIH NIH R01** · CORNELL UNIVERSITY · 1988 · $186,531

## Abstract

The principal objective of this study is the identification and
characterization of the major genetic effects that determine the resistance
level of mice to the intestinal nematode T. spiralis.  Pursuant to this
goal we would further develop our analysis of three major components of
host resistance; namely the rapid expulsion (RE) of ingested larvae, the
rejection of adult worms in the primary infection (Adult lo) and resistance
to migratory newborn larvae (anti-NBL).  Specifically, we wish to
characterize the gene and define linkage for lhe-1, the gene governing RE
in mice.  We will continue our analysis of genetic control of Adult lo and
define the genetic factors that influence anti-NBL immunity.  Data to hand
indicate that major control of each of these responses is determined by
genes that are not linked to the mouse MHC.  A strain analysis of
responsiveness also suggests that each genetic system is independent of the
other.  The strength of the Adult lo response is determined by at least two
non-MHC.  A strain analysis of responsiveness also suggests that each
genetic system is independent of the other.  The strenght of the Adult lo
response is determined by at least two non-MHC genes (AA and BB) which are
co-dominant and additive.  In this study RE, Adult lo and anti-NBL will be
analyzed by single approach that comprises; l) continuing strain survey to
phenotypicaly characterize the response pattern of a wide variety of inbred
strains, including recently derived wild mouse strains.  The objective is
to define the phenotypic variation that exists in mice and identify the
strongest and weakest responder for further genetic analysis; 2) analysis
of selected F1 hybrids to characterize dominance, complementation and
autosomal or sex-linked character, followed by a segregation analysis of F2
and backcross to estimate the numbers of loci involved; 3) linkage analysis
of major genes; for Adult lo (AA and BB) we will also use recombinant
inbred mouse lines; 4) definition of chromosomal position.  We will use the
following approach to examine function for the AA and BB genes.  Antibody
responses to adult worm excretion/secretion antigens will be analyzed to
determine antibody kinetics, repertoire and class-specificity.  Secondly,
we will determine whether AA and BB operate through bone-marrow derived
cells by using radiation chimeras.  Thirdly, we will measure
strain-specific delayed hypersensitivity responses to adult antigens.
These studies will define the function of the genes that we identify,
particulary as it relates to their role in acquired resistance to infection.

## Key facts

- **NIH application ID:** 3126811
- **Project number:** 5R01AI016740-05
- **Recipient organization:** CORNELL UNIVERSITY
- **SAM.gov UEI:** G56PUALJ3KT5
- **Principal Investigator:** ROBIN G BELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $186,531
- **Award type:** 5
- **Project period:** 1981-04-01 → 1989-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126811

## Citation

> US National Institutes of Health, RePORTER application 3126811, GENETICS OF RESISTANCE TO TRICHINELLA SPIRALIS (5R01AI016740-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126811. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*