# HOST DEFENSES TO LEGIONELL PNEUMOPHILA

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 1987 · $101,990

## Abstract

Legionella appear to be a new group of organisms which can be classified as
intracellular pathogens.  Evidence from our laboratory and others indicates
that killed vaccines and serum can protect guinea pigs against
intraperitoneal (i.p.) infection.  We have developed an aerosol model of
infection.  Using this model, we have shown that various vaccination
regimens using acetone- or heat-killed cells protect against i.p. but not
aerosol challenge at comparable LD50 doses.  Lack of protection against
aerosolized organisms occurs in spite of serum antibody.  In this grant we
propose to try a variety of vaccination procedures to find ones which will
give protection against inhaled Legionella, and to investigate the
importance of serum antibody, antibody in lung lavage fluid, and of
cell-mediated mechanisms in host defenses to aerosol challenge as compared
with i.p. challenge.  Further, the ability of several vaccines to confer
cross-protection against different serogroups and species of Legionella
will be tested.

These studies can be expected to increase our knowledge concerning the
mechanisms of immunity to Legionella on both the practical and theoretical
levels, and should also increase our understanding of host defense
mechanisms in the lung.

## Key facts

- **NIH application ID:** 3126843
- **Project number:** 5R01AI016804-06
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **SAM.gov UEI:** QD4MGHFDJKU1
- **Principal Investigator:** Toby K. Eisenstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $101,990
- **Award type:** 5
- **Project period:** 1980-09-01 → 1989-05-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126843

## Citation

> US National Institutes of Health, RePORTER application 3126843, HOST DEFENSES TO LEGIONELL PNEUMOPHILA (5R01AI016804-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126843. Licensed CC0.

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