# IRON TRANSPORT AND VIRULENCE IN SHIGELLA

> **NIH NIH R01** · UNIVERSITY OF TEXAS AT AUSTIN · 1987 · $112,748

## Abstract

Iron transport and iron regulated proteins have been found to be associated
with virulence of Shigella as well as other bacterial pathogens.  An
additional factor associated with virulence of Shigella species is
correlated with the ability of these pathogens to bind the dye Congo red.
Studies proposed for this granting period are designed to answer the
following questions related to iron transport and virulence:  1) How are
the genes for iron transport systems organized and regulated in Shigella
species; 2) What is the molecular basis for binding of Congo red dye by
virulent Shigella; and 3) Are there homologous DNA sequences which confer
invasiveness in virulent Congo red binding species?

Experimental approaches will utilize current recombinant DNA technology to
clone and characterize genes of interest.  Additionally, specific
biochemical and molecular biological techniques have been developed to
facilitate the study of extrachromosomal elements which appear to play a
important role in both gene regulation and virulence of Shigella.

Studies of iron transport and virulence at the molecular level will allow
us to define the role of these factors in host-bacterial interactions.
Characterization of the unique regulatory mechanism(s) associated with
these factors will provide basic information on the control of gene
expression.

## Key facts

- **NIH application ID:** 3126910
- **Project number:** 5R01AI016935-07
- **Recipient organization:** UNIVERSITY OF TEXAS AT AUSTIN
- **SAM.gov UEI:** V6AFQPN18437
- **Principal Investigator:** Shelley M. Payne
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $112,748
- **Award type:** 5
- **Project period:** 1980-09-30 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126910

## Citation

> US National Institutes of Health, RePORTER application 3126910, IRON TRANSPORT AND VIRULENCE IN SHIGELLA (5R01AI016935-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126910. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*