# THE SYNTHESIS OF ANTIBIOTICS

> **NIH NIH R01** · YALE UNIVERSITY · 1988 · $220,126

## Abstract

A renewal of our program directed toward the synthesis of potential antibiotics
is sought.  We hope to achieve the total synthesis and chemical characterization
of pre-tyrosine, the immediate precursor of the aromatic amino acids,
phenylalanine and tyrosine.  This is a logical extension of our work in the
prephenate field which would enable us to probe relationship of structural
modifications and aromatase enzymic recognition in detail.  A related program
involves the synthesis of L-Dopa from glutamate in a fashion which preserves the
optical integrity of the S-amino and chiral center.  Analogs of prephenate and
pretyrosine will be synthesized.

Two new total synthesis efforts are envisioned.  The first deals with the gram
negative antibiotic, bicyclomycin.  The other addresses the interesting
quinonoid antibiotic naphthyridinomycin.

## Key facts

- **NIH application ID:** 3126916
- **Project number:** 5R01AI016943-09
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** SAMUEL J DANISHEFSKY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $220,126
- **Award type:** 5
- **Project period:** 1980-03-01 → 1989-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126916

## Citation

> US National Institutes of Health, RePORTER application 3126916, THE SYNTHESIS OF ANTIBIOTICS (5R01AI016943-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126916. Licensed CC0.

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