# STUDIES OF IMMUNOGLOBULIN AND RIBOSOMAL PROTEIN GENES

> **NIH NIH R01** · RESEARCH INST OF FOX CHASE CAN CTR · 1991 · $332,907

## Abstract

The overall goal of this research is to elucidate mechanisms that regulate
genetic expression at the levels of transcription and RNA processing and
to understand the importance of these mechanisms for B lymphocyte
development and ribosome biogenesis. Studies of immunoglobulin gene
regulation in the mouse will include (i) analysis of the parameters
governing the regulation of heavy chain mRNA production by alternative RNA
processing, (ii) characterization of a novel V(kappa) gene promoter element
and its cognate transcription factor, (iii) an attempt to define the roles
of intronic and downstream enhancers for the establishment and maintenance
of kappa gene transcription, and (iv) an exploration of immunoglobulin gene
regulation in FACS-fractionated populations of B lymphoid cells. Studies
of mouse ribosomal protein genes will include (i) characterization of the
factors that recognize the distinctive promoters of these genes and cloning
of the factor-encoding genes, (ii) elucidation of interactions between the
various promoter elements, and (iii) a study of the importance of intron
splicing for the stabilization and efficient intracellular transpose of
mRNA.

## Key facts

- **NIH application ID:** 3127144
- **Project number:** 2R01AI017330-11
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **SAM.gov UEI:** FF1XVJMDYVR1
- **Principal Investigator:** ROBERT P PERRY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $332,907
- **Award type:** 2
- **Project period:** 1981-01-01 → 1995-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127144

## Citation

> US National Institutes of Health, RePORTER application 3127144, STUDIES OF IMMUNOGLOBULIN AND RIBOSOMAL PROTEIN GENES (2R01AI017330-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127144. Licensed CC0.

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