# STUDIES OF IMMUNOGLOBULIN AND RIBOSOMAL PROTEIN GENES

> **NIH NIH R01** · INSTITUTE FOR CANCER RESEARCH · 1989 · $262,216

## Abstract

I. Overall Goals And Research Strategy

This research is aimed at understanding the molecular mechanisms which
regulate gene expression in mammalian cells.  Two groups of genes in the
mouse:  those responsible for immunoglobulin production and a set of genes
that encode some of the structural proteins of the ribosomes are being
studied.  The immunoglobulin genes belong to the class of so-called "luxury
genes," which are expressed only in highly specialized tissues, in this
case the B-lymphocyte.  These genes are particularly interesting because
their expression changes dramatically during the course of lymphocyte
maturation, both in a qualitative and quantitative sense.  The ribosomal
(r) protein genes are categorized as "housekeeping genes."  They are
expressed in all types of tissue and are coordinately regulated according
to the cells need for new ribosomes.  Recombinant DNA methodology is used
to isolate genes of interest and to produce appropriately modified
derivatives of them.  Gene organization and expression are examined by a
variety of techniques, including DNA and RNA blots, nucleotide sequence
analysis, transcriptional run-on and S1 nuclease protection assays, and
appropriate transfection and transformation experiments with purified gene
fragments.  The knowledge gained by these studies should help establish
some of the molecular bases for cellular differentiation and growth
regulation.

## Key facts

- **NIH application ID:** 3127148
- **Project number:** 5R01AI017330-09
- **Recipient organization:** INSTITUTE FOR CANCER RESEARCH
- **Principal Investigator:** ROBERT P PERRY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $262,216
- **Award type:** 5
- **Project period:** 1981-01-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127148

## Citation

> US National Institutes of Health, RePORTER application 3127148, STUDIES OF IMMUNOGLOBULIN AND RIBOSOMAL PROTEIN GENES (5R01AI017330-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127148. Licensed CC0.

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