# TRYPANOSOME VARIANT ANTIGEN GENES

> **NIH NIH R01** · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · 1988 · $250,214

## Abstract

The overall objective is to elucidate the mechanisms which regulate the
expression of variant surface glycoprotein (VSG) genes in African
trypanosomes.  The immediate objectives are to characterize the molecular
events that mediate antigenic switching (variation) and VSG production
during the life cycle.

Experiments are proposed to:

1. Identify and characterize telomeric regions that are relevant to the
control of VSG gene expression.  These experiments are designed to
elucidate the processes of VSG gene duplication and control of VSG gene
expression.

2. Characterize intrachromasomal VSG genes and their flanking sequences to
elucidate the duplicative (ELC) mechanism of VSG gene expression and
antigenic diversity.

3. Characterize the unit of VSG gene expression and transcriptional changes
associated with changes in VSG gene expression.

4. Identify the molecular mediators of antigenic variation.

## Key facts

- **NIH application ID:** 3127187
- **Project number:** 2R01AI017375-07
- **Recipient organization:** SEATTLE BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** KENNETH D STUART
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $250,214
- **Award type:** 2
- **Project period:** 1982-02-01 → 1993-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127187

## Citation

> US National Institutes of Health, RePORTER application 3127187, TRYPANOSOME VARIANT ANTIGEN GENES (2R01AI017375-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127187. Licensed CC0.

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