# STUDIES IN THE CHEMISTRY OF INTERESTING ANTIBIOTICS

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 1987 · $125,439

## Abstract

This grant will continue development of a major research program to
undertake fundamental studies in the chemistry of recently discovered,
biologically active antibiotics.  The proposed research will investigate
preparation of dioxaspiroketal antibiotics which demonstrate a number of
valuable biological effects.  Examples include:

(1)  Milbemycin alpha 1; the most potent member of a novel group of
macrocyclic lactones with high pesticidal and antihelminthic activity
evoked by unprecedented interference of GABA-mediated neurotransmission in
invertebrates.

(2)  Breynolide; the aglycone of the sulfide-containing antibiotic,
breynin, demonstrating significant in vivo hypocholesterolemic activity in
mammals.

(3)  Additionally, synthetic approaches will be initiated toward linearol,
a hemiketal of the new dolastane family of marine natural products which
have displayed antimicrobial and antileukemic activities.

## Key facts

- **NIH application ID:** 3127360
- **Project number:** 5R01AI017668-08
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **SAM.gov UEI:** YH86RTW2YVJ4
- **Principal Investigator:** DAVID R WILLIAMS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $125,439
- **Award type:** 5
- **Project period:** 1980-06-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127360

## Citation

> US National Institutes of Health, RePORTER application 3127360, STUDIES IN THE CHEMISTRY OF INTERESTING ANTIBIOTICS (5R01AI017668-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127360. Licensed CC0.

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