# IMMUNITY AND VIRUS DISEASE

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 1991 · $212,746

## Abstract

The purpose of this application is to examine the regulation of
virus infections by natural killer (NK) cells and other natural
effector systems and to study how the NK cells interact with
specific immune mechanisms and interferon (IFN) to bring about
clearance of virus infection.  A variety of viral infections will
be used in the mouse model, including infections with lymphocytic
choriomeningitis, murine cytomegalo, herpes simplex, vaccinia,
Pichinde, and mouse hepatitis (MHV) viruses.  These and several
other viruses and variants will be screened for sensitivity to NK
cells in vivo, and this will be correlated with their sensitivity
to NK cell mediated lysis in vitro, with the aim of determining
what property of a virus confers sensitivity to NK cells.  The
regulation of virus infections by lymphokine activated killer (LAK)
cells will be examined, with the aim of developing therapeutic
protocols to control virus infections with these cells.  The
regulation of mouse hepatitis virus infection by a recently
discovered cytotoxic effect of B cells will be examined.  This work
should help define the parameters of natural immunity to virus
infections and will determine whether natural effector cells can
be used to control infections therapeutically.

## Key facts

- **NIH application ID:** 3127368
- **Project number:** 5R01AI017672-12
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **SAM.gov UEI:** MQE2JHHJW9Q8
- **Principal Investigator:** Raymond M Welsh
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $212,746
- **Award type:** 5
- **Project period:** 1980-07-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127368

## Citation

> US National Institutes of Health, RePORTER application 3127368, IMMUNITY AND VIRUS DISEASE (5R01AI017672-12). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3127368. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*