# CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 1987 · $87,256

## Abstract

This grant will continue a research program to investigate the fundamental
chemistry of recently discovered, bioloically active natural products.  Our
plans include two major target areas for study.

Firstly, our continuing efforts for synthesis of the pseudomonic acids A,
B, and C are nearing completion.  These studies have led to the development
of efficient strategies for prepartion of L-carbohydrates and
stereochemically complex oxacyclic systems.

The major emphasis of this proposal describes strategies for highly
convergent, enantiospecific investigations of the chemistry of the
lankacidins.  These unique macrocyclic metabolites display considerable
antitumor activity against L1210 leukemia, B16 melanoma, and solid
lymphosarcoma, in vivo, and are only weakly toxic in mice.  They also show
strong atimicrobial activities, principally against Gram-positive bacteria,
including some strains of clinically resistant isolates.

## Key facts

- **NIH application ID:** 3127376
- **Project number:** 5R01AI017674-06
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **SAM.gov UEI:** YH86RTW2YVJ4
- **Principal Investigator:** DAVID R WILLIAMS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $87,256
- **Award type:** 5
- **Project period:** 1982-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127376

## Citation

> US National Institutes of Health, RePORTER application 3127376, CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS (5R01AI017674-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127376. Licensed CC0.

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