# MAST CELL--EOSINOPHIL INTERACTION IN ALLERGIC INJURY

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1989 · $175,314

## Abstract

Mast cells and eosinophils are closely associated in allergic reactions.
Eosinophil peroxidase (EPO) when combined with hydrogen peroxide (H202) and
a halide forms a strong oxidative system capable of initiating mast cell
degranulation.  EPO also binds firmly to the secreted mast cell granules
(MCG) to form a complex with augmented peroxidatic activity.  Objectives of
this research are 1) to study the formation and biological properties of
the MCG-EPO complex; 2) to study the formation and inactivation of
leukotrienes by phagocytes; 3) to study the induction of mast cell
secretion by agents released by granulocytes; 4) to study the interaction
of mast cell and eosinophil products in the killing of the schistosomula of
Schistosoma mansoni and 5) to study the degradation of mast cell heparin by
granulocyte products.  The overall aim is to study the interaction of mast
cells and eosinophils and the role of this interaction in the
manifestations of allergic diseases and in the host defense against
parasites.

## Key facts

- **NIH application ID:** 3127434
- **Project number:** 5R01AI017758-08
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** SEYMOUR J KLEBANOFF
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $175,314
- **Award type:** 5
- **Project period:** 1981-04-01 → 1993-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127434

## Citation

> US National Institutes of Health, RePORTER application 3127434, MAST CELL--EOSINOPHIL INTERACTION IN ALLERGIC INJURY (5R01AI017758-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127434. Licensed CC0.

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