# STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENS

> **NIH NIH R01** · STANFORD UNIVERSITY · 1987 · $132,788

## Abstract

The long-term objective of our research is to understand the molecular mechanism
by which immune T lymphocytes recognize antigen through self restriction.  It
appears that recognition systems for foreign antigens have evolved from
self-recognition mechanisms and that highly polymorphic self markers, the
histocompatibility antigens are central to this process.

For some years we have been studying the structure of human histocompatibility
(HLA antigens and a complete amino acid sequence for one antigen has been
recently completed.  We are now at a point where comparative studies to answer
the many questions raised by the functionally important, serologically detected
poly-morphism of these molecules can be undertaken.  This goal is aided by the
availability of monoclonal antibodies which provide more reliable tools for
defining these questions.  The problems to be investigated have emerged as a
consequence of our analysis of anti-HLA-A,B,C monoclonal antibodies.

## Key facts

- **NIH application ID:** 3127496
- **Project number:** 5R01AI017892-07
- **Recipient organization:** STANFORD UNIVERSITY
- **SAM.gov UEI:** HJD6G4D6TJY5
- **Principal Investigator:** PETER R PARHAM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $132,788
- **Award type:** 5
- **Project period:** 1981-05-01 → 1989-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127496

## Citation

> US National Institutes of Health, RePORTER application 3127496, STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENS (5R01AI017892-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127496. Licensed CC0.

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