# THE ONTOGENY OF MONONUCLEAR PHAGOCYTES

> **NIH NIH R01** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 1987 · $166,445

## Abstract

The long-range goal of this research is to define the immunobiology of the
macrophage (Mphi).  The immediate objective is to understand the basis of
Mphi functional heterogeneity.  We recently found that mouse bone marrow
cells, immortalized by DNA transfection, produce such high levels of a Mphi
colony-stimulating factor that it is now possible to obtain cloned Mphi
populations with sufficient numbers of cells for phenotypic and functional
analyses.  With the mouse as an experimental model, I will determine (i) if
distinct lineages of antigen-presenting Mphi exist, (ii) whether monoclonal
antibodies detect phenotypically distinct and stable subsets of Mphi, (iii)
if selected homeostatic and host-defense functions of the spleen reside
with phenotypically distinct and independent lineages of Mphi and, (iv)
whether or not distinct factors regulate the proliferation and
differentiation of different Mphi populations.  In addition to their roles
in host-defense and homeostasis, Mphi are now recognized to participate in
the development of certain human diseases such as arteriosclerosis and,
possibly, multiple sclerosis.  If such roles are limited to distinct
subpopulations of Mphi, then the information gained from this study might
make it possible to manipulate them to therapeutic advantage.

## Key facts

- **NIH application ID:** 3127586
- **Project number:** 5R01AI017979-06
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **SAM.gov UEI:** JL4JHE9SDRR3
- **Principal Investigator:** WILLIAM S WALKER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $166,445
- **Award type:** 5
- **Project period:** 1982-07-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127586

## Citation

> US National Institutes of Health, RePORTER application 3127586, THE ONTOGENY OF MONONUCLEAR PHAGOCYTES (5R01AI017979-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127586. Licensed CC0.

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