# REGULATION/SPECIFICITY OF THE IMMUNE RESPONSE TO VIRUS

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1987 · $124,809

## Abstract

This proposal entails the study of the antigenic requirements for
triggering of cytolytic T lymphocytes (CTLs) and the cell interactions that
regulate this response.  Specifically, this study includes the isolation
and characterization of protein antigens from influenza virus, from
uninfected murine cells, and from influenza virus-infected murine cells.
These proteins will be inserted into phospholipid vesicles (liposomes) and
used to define the antigenic requirements for the elicitation of immune
responses by murine T lymphocytes in vitro.  The responses to be studied
are the generation of influenza virus-specific CTLs (i.e., these cells kill
virus-infected, major histocompatibility antigen identical cells) and
helper T cells (i.e., these cells augment the cytolytic activity of CTLs
and may produce helper factors).  Cell lines which respond to influenza
virus antigens will be established and cloned and their response to
purified viral and cell surface antigens will be studied.  The cell
interactions between different functional subsets of lymphocytes which
regulate the CTL response to influenza virus will also be evaluated.  Among
these cell types are helpers, amplifier cells, suppressor cells, and
precursors of cytolytic cells.  It is hoped that the understandings which
develop from these studies can be applied to the human response to
influenza virus, which causes epidemic disease, and later to understanding
the immune response to cancer.  Once we understand the antigens recognized
by CTLs and the cell interactions that regulate this immune response, we
may begin to intervene in order to modulate the host's response to viral
infections and malignancies.

## Key facts

- **NIH application ID:** 3127669
- **Project number:** 5R01AI018083-07
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** CAROL SHOSHKES REISS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $124,809
- **Award type:** 5
- **Project period:** 1981-08-01 → 1989-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127669

## Citation

> US National Institutes of Health, RePORTER application 3127669, REGULATION/SPECIFICITY OF THE IMMUNE RESPONSE TO VIRUS (5R01AI018083-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127669. Licensed CC0.

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