# MOLECULAR BIOLOGICAL STUDIES ON THE HLA SYSTEM

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 1993 · $180,155

## Abstract

This application is for continued support of our efforts to characterize,
at a molecular level, the class I gene family of the human major
histocompatibility complex (MHC). The human MHC is designated the HLA
complex. In addition to maintaining the transplantation barrier between
individuals, molecules encoded by the MHC have a central role in
regulating the immune response. MHC class I molecules are recognized
together with foreign antigens at the cell surface of target cells by the
receptor on cytotoxic T lymphocytes. Multiple genetic loci within the
human MHC encode class I proteins. The experiments described in this
proposal will focus on two interesting aspects of HLA class I molecular
genetics. The molecular characterization of the non-A,B,C class I genes
and their expression will be undertaken to provide insights into their
function. A particularly intriguing question concerns a possible
functional relationship between one or all of the HLA non-A,B,C class I
molecules and cells expressing the gamma/delta receptor molecule. The
second group of experiments will identify and characterize factors
important in the regulation of HLA class I gene transcription. Regulation
of class I gene expression is an important component in determining
whether a cell can interact with T cells in a functionally significant
manner.

## Key facts

- **NIH application ID:** 3127703
- **Project number:** 5R01AI018124-13
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **SAM.gov UEI:** KABJZBBJ4B54
- **Principal Investigator:** Harry T. Orr
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $180,155
- **Award type:** 5
- **Project period:** 1989-09-30 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127703

## Citation

> US National Institutes of Health, RePORTER application 3127703, MOLECULAR BIOLOGICAL STUDIES ON THE HLA SYSTEM (5R01AI018124-13). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3127703. Licensed CC0.

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