# MECHANISMS OF STREPTOCOCCAL-HOST INTERACTIONS

> **NIH NIH R01** · ROCKEFELLER UNIVERSITY · 1993 · $181,640

## Abstract

Work in this laboratory over the past thirty years has demonstrated
that group A streptococci share a number of antigenic determinants with a
variety of host tissues especially with respect to the disease rheumatic
fever (RF).  The recent finding that those individuals susceptible to
contracting rheumatic fever have a genetic marker on their B-cells raises
the interesting question of what role this B-cell antigen plays in the
disease process and how it might influence the host's abnormal immune
response to these cross-reactive streptococcal/mammalian antigens.
     The present proposal will therefore concentrate on the following
areas of investigation: 1. to continue our surveys of the B-cell marker
in RF patients and other individuals.  We will also determine whether
antigen expression is influenced by streptococcal
infections,immunosuppressive agents and whether it is present in other
presumed autoimmune diseases. 2. To continue our efforts to isolate and
characterize the D8/17 antigen expressed on certain B-cell lines. 3. To
search for the gene encoding the D8/17 antigen in cDNA libraries obtained
from the B-cell lines expressing the antigen. 4. To continue our efforts
on determining what role the D8/17 antigen plays in the cellular immune
response to streptococcal antigens in RF and non RF individuals. 5. To
continue our efforts to isolate and characterize those cardiac antigens
cross-reactive with streptococcal antigens and, concomitantly, to
identify at a molecular level in our streptococcal gene bank the genes
encoding streptococcal antigens cross-reactive with cardiac antigens.
     Hopefully these studies will advance our knowledge not only in the
etiopathogenesis of rheumatic fever but also in other diseases of
presumed microbial-host interactions.

## Key facts

- **NIH application ID:** 3127723
- **Project number:** 5R01AI018149-11
- **Recipient organization:** ROCKEFELLER UNIVERSITY
- **SAM.gov UEI:** LHGDNJMZ64Y1
- **Principal Investigator:** JOHN B ZABRISKIE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $181,640
- **Award type:** 5
- **Project period:** 1991-04-01 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127723

## Citation

> US National Institutes of Health, RePORTER application 3127723, MECHANISMS OF STREPTOCOCCAL-HOST INTERACTIONS (5R01AI018149-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127723. Licensed CC0.

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