# RELAPSING FEVER BORRELIA:  BIOLOGY & SEROLOGIC DETECTION

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 1987 · $108,332

## Abstract

There is an enlarging spectrum of tick-transmitted spirochetal diseases.
Lyme disease, a relatively new and clinically important syndrome is caused
by Borrelia burgdorferi (a new species) which is transmitted primarily by
the bite of Ixodes ticks.  The number of human cases and the geographical
area in which the disease is present is increasing in number and size,
respectively.  Recent reports indicate that the North American Borrelia, B.
hermsii can cause chronic infection lasting 10 years with episodes of
exacerbation.  The specific aims of this proposal are:  1) Conduct genetic
studies of the Borrelia 2) Determine optimal conditions for the isolation
of the relapsing fever borrelia 3) Define host and bacterial factors
involved in pathogenesis of borreliosis 4) Determine the in vitro and in
vivo antibotic sensitivity of the relapsing fever borreliae and 5)
Development of test for serodiagnosis of borreleosis.

## Key facts

- **NIH application ID:** 3127727
- **Project number:** 5R01AI018153-06
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **SAM.gov UEI:** KABJZBBJ4B54
- **Principal Investigator:** RUSSELL C JOHNSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $108,332
- **Award type:** 5
- **Project period:** 1982-09-30 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127727

## Citation

> US National Institutes of Health, RePORTER application 3127727, RELAPSING FEVER BORRELIA:  BIOLOGY & SEROLOGIC DETECTION (5R01AI018153-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127727. Licensed CC0.

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