# INFLUENZA B--GENE SEQUENCES

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1988 · $130,464

## Abstract

The overall objective of the work described in this proposal is to
determine the molecular basis of antigenic variation in influenza B viruses
compared with antigenic drift in influenza A.  A detailed understanding of
the mechanism(s) of antigenic variation will enable development of
effective vaccines to control the disease.

The specific aims are:

1. To determine if the sequences of the hemagglutinin genes of influenza B
viruses isolated from human epidemics correlate with their antigenic
properties.

2. To determine if the antigenic structure of the influenza B hemagglutinin
is different to that of influenza A.

3. To determine if the multiple changes we have found in influenza B
hemagglutinin variants are significant in the epidemiology of influenza B.

4. To determine if the differences in antigenicity of the hemagglutinin
between influenza A and B also found in the other surface antigen of the
virus, the neuraminidase.

## Key facts

- **NIH application ID:** 3127752
- **Project number:** 5R01AI018203-07
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** Gillian M Air
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $130,464
- **Award type:** 5
- **Project period:** 1982-04-01 → 1990-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127752

## Citation

> US National Institutes of Health, RePORTER application 3127752, INFLUENZA B--GENE SEQUENCES (5R01AI018203-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127752. Licensed CC0.

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