# IDIOTYPE VACCINE PRODUCING ANTI-INFLUENZA VIRUS IMMUNITY

> **NIH NIH R01** · MOUNT SINAI SCHOOL OF MEDICINE OF CUNY · 1990 · $247,825

## Abstract

The overall objective is to develop a new vaccine approach based on the
preparation of anti-Id antibodies able to stimulate the humoral and
cellular anti-influenza virus immunity. The major thrust of this proposal
is based on our previous studies demonstrating shared idiotopes among
antibodies specific for hemagglutinin and neuraminidase of various virus
subtypes, among antibodies specific for laboratory induced variants and
an interspecies cross-reactive idiotype shared by human and murine anti-
PRB antibodies.

The proposed study bears upon: 1) Preparation of anti-id antibodies
against antibodies specific for laboratory induced variants and studies
of their effects on humoral responses and viral replication. 2)
Immortalization of human B cell clones producing antibodies specific for
the Idx expressed on murine and human anti-PRB antibodies and to
determine in vitro which of these antibodies stimulate influenza virus
specific clones. 3) Studies of the effects of antibodies on cellular
responses and viral replication. The effects of three types of antibodies
will be studied a) anti-TCR antibodies, b) a hybrid bifunctional antibody
(specific for TCR of CTL and HA of influenza virus) which can efficiently
focus CTL on infected target cells. c) a genetically engineered antibody
containing an inserted viral epitope.

These studies are aimed to determine the enhancing effects of anti-id
antibodies on immune reaction against influenza virus, a system in which
vaccines produced by classical approaches has not succeed in overcoming
epidemics resulting from a high potential for natural antigenic variation
of the virus.

## Key facts

- **NIH application ID:** 3127843
- **Project number:** 5R01AI018316-10
- **Recipient organization:** MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
- **Principal Investigator:** CONSTANTIN A BONA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $247,825
- **Award type:** 5
- **Project period:** 1981-08-01 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127843

## Citation

> US National Institutes of Health, RePORTER application 3127843, IDIOTYPE VACCINE PRODUCING ANTI-INFLUENZA VIRUS IMMUNITY (5R01AI018316-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127843. Licensed CC0.

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