# ORGAN TRANSPLANTATION

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 1989 · $65,139

## Abstract

Studies are proposed which aim to gain further information that is relevant
to organ transplantation.  An easily quantitated in vivo model, which
allows accurate assay of rejection and employs transplantation of islets of
Langerhans under the kidney capsule, will be employed for experiments to
ascertain the cellular basis of rejection in a variety of immunogenetic
disparities and sensitization states.  Similar immunogenetic and
sensitization situations will be studied in vitro in an attempt to evaluate
the in vivo relevance of in vitro findings; studies will be performed in
both mouse and man.  Limiting dilution analyses, cloning of T (and possibly
other) lymphocytes and functional characterization of these cells will be
applied to both in vivo and in vitro models.  Special emphasis will be
given to the further characterization of the antigen driven, helper-cell
independent cytotoxic T lymphocyte (HITc), which was described from our
laboratories in both mouse and man and which appears to combine the
attributes of helper T lymphocytes and conventional cytotoxic T
lymphocytes.  Neonatal-tolerance will be induced under a variety of
circumstances to study further the phenomenon that we refer to as
"composite determinant recognition" in which mice neonatally tolerized to
(class I + class II) disparities demonstrate hyporeactivity in adult life
to the class (I+II) disparity but are normally (or nearly so) reactive to
the class I or the class II disparity presented alone.  Studies of HLA
restricted responses and signals required for activation, maturation and
expansion of cytotoxic T lymphocytes are also proposed.  The overall
experimental plan is aimed at obtaining information that will allow
successful organ transplantation of not only endocrine organs, such as
islets, but hopefully other tissues as well.

## Key facts

- **NIH application ID:** 3127852
- **Project number:** 3R01AI018326-08S1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **SAM.gov UEI:** KABJZBBJ4B54
- **Principal Investigator:** FRITZ H BACH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $65,139
- **Award type:** 3
- **Project period:** 1980-12-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127852

## Citation

> US National Institutes of Health, RePORTER application 3127852, ORGAN TRANSPLANTATION (3R01AI018326-08S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127852. Licensed CC0.

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