# VIRULENCE FACTORS OF UROPATHOGENIC ENTEROBACTERIACEAE

> **NIH NIH R01** · BAYLOR COLLEGE OF MEDICINE · 1989 · $130,760

## Abstract

Urinary tract infections (UTI) are among the most common human infections
and may have serious sequelace. Most UTI are caused by members of the
bacterial family Enterbacteriaceae. UTI results from the interaction of
Bacteria with a susceptible host. Each step in the pathogenic process is
determined by the balance between host. Each step in the pathogenic
process id determined by the balance between host resistance and
bacterial virulence. The virulent strain possesses determinants required
to colonize the bowel, ascend into and persist in the urinary tract and
induce infection. The object of this research is to characterize and
compare, using modern genetic techniques, bacterial genes that encode
virulence determinants and to demonstrate the role of these virulence
genes in UT1. More specifically, a variety of methods will be used for
the genetic, physical and functional analysis of receptor specific
proteins that mediate adherence of Proteus mirabilis and Escherichia coli
to human uroepithelium.

## Key facts

- **NIH application ID:** 3127960
- **Project number:** 2R01AI018462-07A1
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **SAM.gov UEI:** FXKMA43NTV21
- **Principal Investigator:** RICHARD A. HULL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $130,760
- **Award type:** 2
- **Project period:** 1982-01-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127960

## Citation

> US National Institutes of Health, RePORTER application 3127960, VIRULENCE FACTORS OF UROPATHOGENIC ENTEROBACTERIACEAE (2R01AI018462-07A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127960. Licensed CC0.

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