# IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES

> **NIH NIH R01** · CASE WESTERN RESERVE UNIVERSITY · 1989 · $184,737

## Abstract

This is an application for competitive renewal of Grant AI-18471.
The long-term objectives of this proposal are to elucidate
mechanisms of tuberculin-specific immunosuppression in human
tuberculosis and to examine the basis for the association between
HLA-DRw8 and active pulmonary tuberculosis.  The specific aims
are:  1) to examine the phenotype, immunoregulatory function and
selected mediators of adherent mononuclear cell subpopulations in
tuberculosis; 2) to characterize regulation of tuberculin responses
by nonadherent lymphocytes in tuberculosis by determining the
phenotype and state of activation of suppressor lymphocytes; and
3) to explore the basis for genetically-determined susceptibility to
tuberculosis by establishing levels of response to mycobacterial
antigens and patterns of immunoregulation in patients with and
without the HLA-DRw8 phenotype and their families.  The
methodology for achieving these goals involves techniques of
cellular immunology (characterization of phenotypes and state of
activation/differentiation of blood mononuclear cells by
reactivity with monoclonal antibodies and indirect
immunofluorescence/cytofluorometry, and cell cycle analysis;
characterization of suppressor cell function by cell separation and
reconstitution protocols, and assay of antigen-induced
blastogenesis and production of interleukin-2; development of T
cell clones), immunochemistry (immunoabsorbent chromatography
using monospecific and monoclonal antibodies to study the role of
interleukin-1 in immunosuppression by adherent mononuclear
cells) and immunogenetics (association of HLA-types with
tuberculosis, family studies, linkage analysis).  This is a health-
related project.

## Key facts

- **NIH application ID:** 3127975
- **Project number:** 5R01AI018471-07
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** Jerrold J. Ellner
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $184,737
- **Award type:** 5
- **Project period:** 1982-01-01 → 1990-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127975

## Citation

> US National Institutes of Health, RePORTER application 3127975, IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES (5R01AI018471-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127975. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*