# EFFECT OF LOW MEASLES ANTIBODY TITER ON INFANT IMMUNITY

> **NIH NIH R01** · YALE UNIVERSITY · 1987 · $145,446

## Abstract

The objective is to improve the effectiveness of measles and tetanus
vaccines in developing countries, thereby diminishing mortality and
debility there, reducing measles virus importation to the USA and learning
more about the identity of the immunoglobulin which protect against measles
and the factors which control their transport to the fetus.  Specifically
we will:

1. Identify the factors(s) which determine the age at which a child becomes
susceptible to measles and responsive to vaccine.

2. Study the relative roles in protection from disease of immunologlobulin
idiotypes directed toward the four major structural proteins of measles
virus.

3. Quantitate the response of the human adult to repeated doses of tetanus
toxiod and to set up practical guidelines for determination of vaccine
needs in diverse populations.

4. Seek to learn more about the mechanism of transplacental movement of
immunoglobulins in humans.

## Key facts

- **NIH application ID:** 3127997
- **Project number:** 5R01AI018502-06
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** FRANCIS L BLACK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $145,446
- **Award type:** 5
- **Project period:** 1982-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3127997

## Citation

> US National Institutes of Health, RePORTER application 3127997, EFFECT OF LOW MEASLES ANTIBODY TITER ON INFANT IMMUNITY (5R01AI018502-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3127997. Licensed CC0.

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