# MOLECULAR EVENTS IN ANTIGEN RECOGNITION

> **NIH NIH R01** · NATIONAL JEWISH HEALTH · 1987 · $230,647

## Abstract

This proposal has two main areas of investigation:  1) to examine B cell
antigen presentation to T cells and 2) to characterize antigen processing
by macrophages and B cells.  Using functional studies, we will examine the
ability of B cells to present antigenic determiants to T cells in a manner
similar to macrophages.  We will determine if B cell presentation of
antigen to T cells is MHC restricted.  In addition, we will test the
ability of murine lymphoma cells and neonatal B cells to present antigen to
T cells.  Using functional, biochemical and immunochemical techniques we
will study the physical and immunological characteristics of macrophage and
B cell antigen processing.  Characterization will include studies of
antigen degradation and the involement of lysosomes in antigen processing.
Using both intact macrophages and B cells and subcellular fractions of
these cells we will study the characteristics of immunologically active
processed antigen and its possible association with MHC gene products.

## Key facts

- **NIH application ID:** 3128060
- **Project number:** 3R01AI018634-05S1
- **Recipient organization:** NATIONAL JEWISH HEALTH
- **SAM.gov UEI:** VLQKFEEJ3NE9
- **Principal Investigator:** HOWARD M. GREY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $230,647
- **Award type:** 3
- **Project period:** 1982-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128060

## Citation

> US National Institutes of Health, RePORTER application 3128060, MOLECULAR EVENTS IN ANTIGEN RECOGNITION (3R01AI018634-05S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128060. Licensed CC0.

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