# CYTOMEGALOVIRUS EPIDEMIOLOGY AND SEXUAL TRANSMISSION

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1987 · $191,077

## Abstract

The overall objective of this proposal is to investigate the natural
history of sexually acquired cytomegalovirus (CMV) infection.  Using both
prevalence surveys and prospective cohort studies we will systematically
analyze and correlate CMV infection with sexual practices, level of sexual
activity, changes in sex partners and other correlates of sexual activity.
Cohort studies to assess the frequency of acquisition of disease, anatomic
sites and duration of excretion of CMV from genitourinary sites in clients
of sexually transmitted disease clinics, university health center
populations, and adolescents attending medical clinics will be performed.
Sex partners of persons with and without CMV infection will be followed to
evaluate the frequency of CMV transmission from contact with persons with
persistent or chronic CMV infection.  Restriction enzyme typing will be
utilized to compare isolates from sex partners in order to distinguish
endogenous relapse with exogenous reinfection.  Both local and systemic
host immune responses to specific viral polypeptides using
radioimmunoprecipitation and Western blot analysis will be performed.  In
situ hybridization techniques for the detection of CMV DNA will be
performed in order to assess the sites of CMV in the genitourinary tract.
Comparison of conventional isolation methods, detection of CMV antigen with
monoclonal antibodies and CMV DNA by Southern blotting and in situ
hybridization methods with clinical expression and transmission of disease
will further our understanding of the natural history and persistence of
CMV infection of the genitourinary tract.

## Key facts

- **NIH application ID:** 3128092
- **Project number:** 5R01AI018649-06
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** Lawrence Corey
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $191,077
- **Award type:** 5
- **Project period:** 1982-01-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128092

## Citation

> US National Institutes of Health, RePORTER application 3128092, CYTOMEGALOVIRUS EPIDEMIOLOGY AND SEXUAL TRANSMISSION (5R01AI018649-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128092. Licensed CC0.

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