# CONTROL MECHANISMS IN IMMUNOGLOBULIN PRODUCTION

> **NIH NIH R01** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 1988 · $95,038

## Abstract

I propose to test the idea that normal immunoglobulin production is
controlled by specific cellular interactions.  Consistent with this
hypothesis is the evidence recently obtained that genetically unexpected
(latent) variable region allotypes and allotypic internal images can be
routinely induced by immunizing rabbits or mice with anti-allotype
antibody.  In the studies described here, I intend to define the
mechanism(s) for induction of unexpected allotypes and to determine the
molecular basis for latent allotypes and allotypic internal images.  I will
assess the ability of anti-immunoglobulin antibodies to cause shifts in
allotype-specific and isotype-specific regulatory influences that operate
during chronic allotype suppression, normal immunoglobulin production, and
antigen-induced antibody responses.  The major experimental systems and
methods to be employed are in vivo immunizations, in vitro culturing of
cells from allotype-defined and MHC-matched rabbits, and monoclonal
antibodies that display rabbit allotypic images.  The information obtained
should help clarify our understanding of immune system homeostasis and be
of relevance for the biological modification of human immunodeficiency
states such as AIDS and the immunotherapy of cancer.

## Key facts

- **NIH application ID:** 3128279
- **Project number:** 5R01AI018880-05
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **SAM.gov UEI:** JL4JHE9SDRR3
- **Principal Investigator:** DENNIS W METZGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $95,038
- **Award type:** 5
- **Project period:** 1983-04-01 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128279

## Citation

> US National Institutes of Health, RePORTER application 3128279, CONTROL MECHANISMS IN IMMUNOGLOBULIN PRODUCTION (5R01AI018880-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128279. Licensed CC0.

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