# T CELL RESPONSES TO NON-H-2 ANTIGENS OF CHROMOSOME 17

> **NIH NIH R01** · BAYLOR COLLEGE OF MEDICINE · 1987 · $119,376

## Abstract

This is an application for study of cell-mediated immune responses to
antigens encoded on the murine 17th chromosome outside, but adjacent to,
the H-2 complex as traditionally defined.  The major portion of this work
will focus on gene products of the Qa-1/Tla region.  These molecules,
including the thymus leukemia antigen, appear most likely to function as
differentiation antigens both in normal lymphocyte ontogeny and functional
diversification of lymphocyte subsets, and in the development of T cell
leukemias and lymphomas.  We will extend our ongoing studies on H-2
nonrestricted T cell-mediated cytotoxic reactions induced by antigens of
this region.  A library of cytotoxic T cell clones with specificy for these
determinants will be developed.  Antigenic structures and polymorphisms
recognized by cytotoxic T cells will be compared with those defined
serologically with conventional and monoclonal antibodies.  The role of H-2
genes in expression of Qa-1 antigens and in the control of cytotoxic T cell
responses to Qa-1 will be defined.  We will investigate regulation of T
cell responses to Qa-1 antigens in autoimmune NZB mice and normal mice,
with particular interest in defining physiological control processes.
Receptor specificity for Qa-1 recognition by T cells will be compared with
that for recognition for major histocompabitility complex antigens and for
recognition of conventional antigens.

## Key facts

- **NIH application ID:** 3128285
- **Project number:** 5R01AI018882-05
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **SAM.gov UEI:** FXKMA43NTV21
- **Principal Investigator:** ROBERT R. RICH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $119,376
- **Award type:** 5
- **Project period:** 1983-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128285

## Citation

> US National Institutes of Health, RePORTER application 3128285, T CELL RESPONSES TO NON-H-2 ANTIGENS OF CHROMOSOME 17 (5R01AI018882-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128285. Licensed CC0.

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