# IMMUNOREGULATION IN SCHISTOSOMIASIS

> **NIH NIH R01** · TUFTS UNIVERSITY BOSTON · 1992 · $221,175

## Abstract

This proposal describes the continuation of studies to investigate basic
immunologic and immunopathologic mechanisms in experimental murine
schistosomiasis mansoni.  They involve the identification of the major
stimulatory egg antigens responsible for eliciting T cell-mediated
granulomatous hypersensitivity and immunopathologic damage, as well as the
elucidation of the basic mechanisms that underlie the phenomenon of
immunological down-regulation (immunomodulation), characteristic of this
disease.

T cell clones will be produced to analyze the basis of the cell-mediated
antischistosomal immune response.  Clone phenotypes will be established.
Clonality will be verified by Southern blot analysis.  Fine specificities
recognized by the clones will be ascertained by stimulation with,
individual antigenic egg components following fractionation by
agarose-isoelectric focusing and high pressure liquid chromatography,
and/or identification by monoclonal antibody analysis.  The genetic
restrictions of the response will be determined.  Functional capabilities
of SEA-specific T cell clones will be ascertained in vivo.

The hypothesis that granuloma macrophages induce a state of
unresponsiveness to antigen in specific T cell clones will be tested.  This
may offer a novel explanation for the phenomenon of immunomodulation, which
has, so far, defied satisfactory understanding.  This hypothesis will also
be implemented by assessing the effect of specific T cell clone
unresponsiveness-inducing regimens on the development and course of a
challenge schistosomal infection in vivo.

These experiments will contribute to the understanding of the basic
immunological mechanisms in schistosomiasis, and are expected to have a
direct impact in the development of preventive and therapeutic approaches
against the pathology resulting from this disease.

## Key facts

- **NIH application ID:** 3128304
- **Project number:** 2R01AI018919-07A4
- **Recipient organization:** TUFTS UNIVERSITY BOSTON
- **SAM.gov UEI:** C1F5LNUF7W86
- **Principal Investigator:** MIGUEL J. STADECKER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $221,175
- **Award type:** 2
- **Project period:** 1983-01-01 → 1994-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128304

## Citation

> US National Institutes of Health, RePORTER application 3128304, IMMUNOREGULATION IN SCHISTOSOMIASIS (2R01AI018919-07A4). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128304. Licensed CC0.

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