# BICYCLOMYCIN SYNTHESIS AND ANTIBIOTIC BIOMECHANISM

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 1987 · $77,470

## Abstract

The objective of the proposed research is the total synthesis of the novel
antibiotic bicyclomycin in optically active form and of select bicyclomycin
analogs to be used in evaluating the chemical mechanism of antibacterial
action of bicyclomycin.  New synthetic methods for constructing the
bicyclomycin ring system will be investigated.  The synthetic strategem is
of sufficient bravity and versatility to allow the elaboration of
bicyclomycin and all synthetic analogs from a few common intermediates.  By
these methods, the chemical structural and dynamic properties of the
bicyclomycin ring system as a "latent" Alpha,Beta-unsaturated pryuvamide
(Michael acceptor) will be investigated.

## Key facts

- **NIH application ID:** 3128351
- **Project number:** 5R01AI018957-06
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **SAM.gov UEI:** LT9CXX8L19G1
- **Principal Investigator:** Robert Michael Williams
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $77,470
- **Award type:** 5
- **Project period:** 1982-05-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128351

## Citation

> US National Institutes of Health, RePORTER application 3128351, BICYCLOMYCIN SYNTHESIS AND ANTIBIOTIC BIOMECHANISM (5R01AI018957-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128351. Licensed CC0.

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