# STRUCTURE OF ANTIGENIC SITES ON INFLUENZA VIRUS PROTEINS

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1989 · $128,047

## Abstract

The objective of the research is to design ways of controlling epidemic
influenza in the human population.  If the molecular interactions involved
in establishing influenza infection and in resisting this infection can be
determined, it may be possible to design rational control measures which
are derived from knowledge of the nature of the interactions between
antibodies and influenza antigens, and between virus enzymes and substrates.

The specific aims of the project are:

1. To determine the interactions involved in binding antibody to influenza
virus neuraminidase (NA), to identify the size and shape of the
antibody-binding surface on the NA and to determine the features which give
specificity to the complementarity determining regions of anti-NA
antibodies.

2. To identify the essential features of the catalytic and
substrate-binding site(s) of the NA, and determine the mechanism of
catalysis.  Hence, inhibitors can be designed to control influenza
infection by quashing NA function.

3. To obtain continuous expression of active influenza virus NA in a range
of cell types using a retrovirus vector to integrate the NA gene stably
into the host genome.

## Key facts

- **NIH application ID:** 3128513
- **Project number:** 5R01AI019084-07
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** Gillian M Air
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $128,047
- **Award type:** 5
- **Project period:** 1983-04-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128513

## Citation

> US National Institutes of Health, RePORTER application 3128513, STRUCTURE OF ANTIGENIC SITES ON INFLUENZA VIRUS PROTEINS (5R01AI019084-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128513. Licensed CC0.

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