# THE SYNTHESIS OF ROSARAMYCIN AND RELATED SYSTEMS

> **NIH NIH R01** · UNIVERSITY OF ROCHESTER · 1987 · $117,967

## Abstract

The specific aims of this grant include two total syntheses which are based
on aldol chemistry developed in these laboratories three years ago.  This
methodology utilizes the chemistry of enolate systems arising from
vinylogous urethanes.  The first of these synthetic targets is the
macrolide antibiotic rosaramycin (1), a molecular system of considerable
biological interest.  Our synthetic effort on this molecule is in its third
year.  The progress report and first part of the experimental design and
methods section of this proposal will discuss the current status of this
problem and our intended future efforts on it, respectively.

The second part of this proposal involves a construction of the seco-acid
of erythromycin (2).  In this section, we will propose a detailed study of
the methodology we intend to employ for the synthesis along with a
description of the synthetic route itself.

## Key facts

- **NIH application ID:** 3128532
- **Project number:** 5R01AI019133-06
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **SAM.gov UEI:** F27KDXZMF9Y8
- **Principal Investigator:** RICHARD H SCHLESSINGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $117,967
- **Award type:** 5
- **Project period:** 1982-09-30 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128532

## Citation

> US National Institutes of Health, RePORTER application 3128532, THE SYNTHESIS OF ROSARAMYCIN AND RELATED SYSTEMS (5R01AI019133-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128532. Licensed CC0.

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