# T LYMPHOCYTE AND MACROPHAGE INTERACTIONS

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1988 · $191,715

## Abstract

The major objective of this project is to further define the role of major
histocompatibility complex (MHC) antigens in immunocompetent cell
interactions and their involvement in the immunogenic association with
exogenous antigens.  The proposed research is directed toward understanding
the nature of T lymphocyte recognition of macrophage-associated antigens
and involves a combination of cellular immunological and peptide chemistry
approaches.  The rational is that by first defining the exogenous antigenic
determinants for T cell responsiveness using small synthetic peptide
antigens, we may be able to characterize the imunogenic complex presented
by macrophages and the antigen recognition process of T cells.  Using this
approach we will investigate:  1) the critical amino acids of small peptide
antigens that are directly recognized by T cells and macrophages; 2)
macrophages and T cell structures that specifically bind antigenic
determinants of peptide fragments; 3) how macrophages process small
peptides to create the immunogenic moiety and the role of macrophage
degradation of large proteins to immunogenic fragments; 4) the mechanisms
of genetic regulation of immune responsiveness (Ir gene function) to small
peptide antigens and the cellular interactions influencing responsiveness;
and 5) the relationship between I region-associated (Ia) antigen expression
and Ir gene function.  The results of these studies should contribute to an
understanding of the signals required for lymphocyte activation by
elucidating  MHC gene product interaction with exogenous antigens and their
role in imunocompetent cell interactions.

## Key facts

- **NIH application ID:** 3128620
- **Project number:** 5R01AI019273-07
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** RODERICK NAIRN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $191,715
- **Award type:** 5
- **Project period:** 1981-12-31 → 1991-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128620

## Citation

> US National Institutes of Health, RePORTER application 3128620, T LYMPHOCYTE AND MACROPHAGE INTERACTIONS (5R01AI019273-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128620. Licensed CC0.

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