# SURFACE PROTEINS OF NEISSERIA GONORRHOEAE

> **NIH NIH R01** · ROCKEFELLER UNIVERSITY · 1987 · $127,475

## Abstract

The studies will focus on the description of antigenic epitopes on
protein I and protein III.  We have a large number of clones
producing antibodies to PIB proteins and we have the sequence of
a PIB gene nearly complete.  Using deletion mutants and synthetic
peptides the reactive eptiopes will be defined.

It has recently been demonstrated that human antibodies to PIII
are able to block bactericidal activity of antibodies directed to
other surface antigens.  We have completed the sequence of the
structural gene of PIII and this has allowed the proposal of a
model of the disposition of this protein in the outer membrane.
We are currently isolating PIII reactive monoclonal antibodies and
will determine the antigenic epitopes of PIII, their surface
exposure, and which one generates the blocking antibodies.

## Key facts

- **NIH application ID:** 3128803
- **Project number:** 5R01AI019469-05
- **Recipient organization:** ROCKEFELLER UNIVERSITY
- **SAM.gov UEI:** LHGDNJMZ64Y1
- **Principal Investigator:** Emil C. Gotschlich
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $127,475
- **Award type:** 5
- **Project period:** 1982-02-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128803

## Citation

> US National Institutes of Health, RePORTER application 3128803, SURFACE PROTEINS OF NEISSERIA GONORRHOEAE (5R01AI019469-05). Retrieved via MORVS 2026-11-01 from https://api.morvs.ai/grant/nih/3128803. Licensed CC0.

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