# CELL COOPERATION IN IMMUNE RESPONSES

> **NIH NIH R01** · MEDICAL BIOLOGY INSTITUTE · 1987 · $187,427

## Abstract

The overall objective of this research program is to further our
understanding of regulatory mechanisms controlling the immune system.  This
objective will be approached by delineating the various mechanisms by which
regulatory cell interactions, and the molecules involved in such
interactions, are ultimately translated into immune responses.  Since there
is good reason to believe that the IgE antibody system provides a
particularly sensitive and illuminating window through which to view
mechanisms of regulatory control of the immune system, we are focusing our
attention on the regulatory processes governing the IgE system.  Recently,
we have discovered a family of regulatory molecules that interact with one
another, and with certain definable lymphoid cells that appear to be
selectively concerned with the IgE system--namely, those that express
IgE-specific Fc receptors (FcRepsilon).  The cascade of cellular and
molecular events in which these constituents play definable roles could
reflect processes that are inherent in the control mechanisms concerned
with other aspects of the immune system.  Therefore, this research program
is oriented toward extrapolating information derived from studies defining
the cellular and molecular interactions that control expression of IgE in
such a way as to guide the development of new experimental approaches for
delineating control mechanisms participating in expression of other
immunoglobulin isotypes, and certain types of cell mediate immune
responses, in experimental animals.  Collectively, these studies should
considerably widen our understanding of how immune regulation evolves and,
under normal circumstances, maintains a steady state of maximal protection
of the host.

## Key facts

- **NIH application ID:** 3128813
- **Project number:** 5R01AI019476-06
- **Recipient organization:** MEDICAL BIOLOGY INSTITUTE
- **Principal Investigator:** DAVID H KATZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $187,427
- **Award type:** 5
- **Project period:** 1982-03-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128813

## Citation

> US National Institutes of Health, RePORTER application 3128813, CELL COOPERATION IN IMMUNE RESPONSES (5R01AI019476-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128813. Licensed CC0.

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