# SYNTHESIS OF MILBEMYCINS AND RELATED STUDIES

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 1987 · $123,525

## Abstract

Studies are proposed to execute a covergent, enantioselective synthesis of
several members of the class of milbemycins and avermectins.  The
milbemycins are potent antimicrobial agents and the avermectins show
exceptional anthelminthic properties with low mammalian toxicity.

Additional studies are outlined to develop an enantioselective anti aldol
condensation which could have wide application in the synthesis of
bio-active natural products.  Applications to the milbemycin-avermectin
problem are discussed as well as synthetic approaches to nonactin, an
antibiotic ionophore, the Prelog Djerassi lactone, and the tumor promoting
neurotoxin, aplysiatoxin.

## Key facts

- **NIH application ID:** 3128870
- **Project number:** 5R01AI019544-05
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **SAM.gov UEI:** D3LHU66KBLD5
- **Principal Investigator:** MICHAEL T. CRIMMINS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $123,525
- **Award type:** 5
- **Project period:** 1983-03-01 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128870

## Citation

> US National Institutes of Health, RePORTER application 3128870, SYNTHESIS OF MILBEMYCINS AND RELATED STUDIES (5R01AI019544-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128870. Licensed CC0.

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