# ARBOVIRUS GROWTH IN CULTURED INSECT CELLS

> **NIH NIH R01** · UNIVERSITY OF TEXAS AT AUSTIN · 1992 · $124,612

## Abstract

Sindbis virus will be employed as a model insect-vectored virus in studies
investigating the interaction of these agents with the invertebrate hosts.
The development of sindbis virus in tissue-cultured mosquito cell will be
studies in an attempt to learn how this virus is able to establish state
of infection in these cells without the gross cytopathic effect and cell
death that occurs in cultured vertebrate cells.  The morphological,
genetic and biochemical/ molecular biological events occurring in the
vertebrate cells will be determined and compared to analogous processes in
cultured vertebrate cells.  Particular attention will be given to the
structure and function of a non-interferon antiviral compound produced
specifically by the infected mosquito cell which inhibits the growth of
the infecting virus.

Arthropod-vectored, virus-induced diseases of man and domestic animals are
in resurgence in the United States.  Tissue-cultured arthropod cells are
under consideration as a substitute for the production of vaccines.  The
information obtained from this study will provide important in
understanding the virus,    insect, cell relationship and establishment of
non-toxic infection leading to transovarial transmission of insect viruses
in nature and the disease process in man.

## Key facts

- **NIH application ID:** 3128880
- **Project number:** 5R01AI019545-06
- **Recipient organization:** UNIVERSITY OF TEXAS AT AUSTIN
- **SAM.gov UEI:** V6AFQPN18437
- **Principal Investigator:** Dennis T Brown
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $124,612
- **Award type:** 5
- **Project period:** 1983-07-01 → 1992-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128880

## Citation

> US National Institutes of Health, RePORTER application 3128880, ARBOVIRUS GROWTH IN CULTURED INSECT CELLS (5R01AI019545-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128880. Licensed CC0.

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