# MURINE B LYMPHOCYTE DEVELOPMENT

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1988 · $109,771

## Abstract

It is not known how the immune system develops during ontogeny
to become a connected network of interacting T and B cells.  The
long-term goal of this on-going research project is to solve this
problem using the T15/PC murine system as a model.  Our
working hypothesis is that there exist finite resources allocated to
B cell differentiation during ontogeny.  As a consequence, B cell
precursors compete with each and some become winners
(dominant idiotypes).  T15+ B cell clones have an ontogenetic
advantage and compete successfully to reach a developmental
stage where IghC-linked network selection occurs to preserve
dominant expression of this idiotype.  This proposal deals with
experiments designed to reconstruct the cellular interactions that
bring about T15 dominance.  I propose a series of in vivo
experiments to analyze the role of antigen, internal images of PC,
helper T and B cell subsets in the regulation of T15 expression.
Our research addresses important and unresolved issues in
immunoregulation:  idiotype vs non-idiotype-specific effects, the
development of the lymphocyte network and the interdependence
of T and B cell repertoires.

## Key facts

- **NIH application ID:** 3128925
- **Project number:** 2R01AI019589-04A1
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** Jose Ramon Quintans
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $109,771
- **Award type:** 2
- **Project period:** 1984-09-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3128925

## Citation

> US National Institutes of Health, RePORTER application 3128925, MURINE B LYMPHOCYTE DEVELOPMENT (2R01AI019589-04A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3128925. Licensed CC0.

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