# IMMUNOGENETICS OF H-3 AND M1S REGIONS

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1987 · $210,370

## Abstract

The most significant finding has been the discovery that the Ly-17
alloantigen is identical with the FcGamma2b receptor (FcR).  As previous
genetic evidence had inseparably linked the Ly-17 gene to the Mls locus on
chromosome 1 we now postulate that FcR serves as the long-sought Mls
product.  Whereas a number of longstanding observations are in support of
this hypothesis, the most notable experimental fact is the ability of Fc
fragments to activate T helper (TH) cells.

We propose to produce further evidence that Ly-17 serves as the Mls
product.  Ly-17 antigen will be purified and characterized biochemically.
Peptide and amino acid sequence analyses will be performed.  Ly-17 will be
implanted via fusogenic liposomes in suitable antigen-presenting cells
(APC) to test whether this maneuver will confer transient Mls stimulatory
capacity.  The potentially important spatial association of Ly-17 and Ia
reported earlier will be re-evaluated.

Finally, we will investigate the mechanism of Mls activation.  Two models
are suggested.  The first assumes that a positive signal, emanating from
Ly-17 (FcR) to an unidentified acceptor A, is enhanced in the
Mls-mismatched APC-TH pair, leading in synergy with the autoreactive Ia-Ti
interaction to TH activation ("heteroclicity" model).  In the second model
the opposite assumption is made that Ly-17 (FcR) normally imparts a
dampening signal to TH.  In the Mls mismatched APC-TH pair this signal may
not function properly, allowing TH activation through auto-MLR ("decontrol
of autoreactivity" model).

## Key facts

- **NIH application ID:** 3129051
- **Project number:** 5R01AI019682-05
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** ULRICH G HAMMERLING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $210,370
- **Award type:** 5
- **Project period:** 1983-03-01 → 1989-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129051

## Citation

> US National Institutes of Health, RePORTER application 3129051, IMMUNOGENETICS OF H-3 AND M1S REGIONS (5R01AI019682-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129051. Licensed CC0.

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