# IMMUNITY AND LATENCY TO CHLAMYDIAL INFECTIONS

> **NIH NIH R01** · UNIVERSITY OF WISCONSIN-MADISON · 1990 · $120,170

## Abstract

The major emphasis of work proposed in this project will continue
to be directed toward an increased understanding of immune
responses relevant to protection against chlamydial disease and
defining how various elements of immunity to chlamydia contribute
to protection, persistence, pathologic charges and recovery from
infection.  Much of the proposed work will involve studying of a
murine model of protective immunity to chlamydia, recovery from
chlamydial disease and persistence subsequent to either
immunization or infection.  Critical parameters related to cytokine
mediated events also will be tested in vitro using human cell lines
and, when appropriate, cytokines to evaluate if information
obtained in the murine system applies to the human condition as
well.  The role of cytokines in mediating persistence, recovery
from acute disease and cytolytic activity directed at infected host
cells will be further evaluated.  Renewed emphasis also will be
placed on determining the extent of persistence subsequent to acute
disease or induction of protective immunity following inoculation
of viable chlamydial inocula.  Cellular cloning of lymphocytes
coupled with passive transfer experiments will provide evidence
concerning the functional requirements for protective immunity and
the chlamydial antigens that trigger induction of critical
lymphocyte subpopulations.  Innate defense will be compared between
mouse strains that have recently been identified as differing in
their susceptibility to chlamydia by approximately 100 million
lethal inoculum doses.  Finally, cross-protection studies will help
elucidate the degree of immunity conferred between strains that
differ to various extents in their antigenic composition.

## Key facts

- **NIH application ID:** 3129195
- **Project number:** 5R01AI019782-06
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **SAM.gov UEI:** LCLSJAGTNZQ7
- **Principal Investigator:** Gerald Irwin Byrne
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $120,170
- **Award type:** 5
- **Project period:** 1982-08-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129195

## Citation

> US National Institutes of Health, RePORTER application 3129195, IMMUNITY AND LATENCY TO CHLAMYDIAL INFECTIONS (5R01AI019782-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129195. Licensed CC0.

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