# HUMAN T CELL ANTIGEN-RECOGNITION STRUCTURES

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1987 · $194,076

## Abstract

Definintion of antigen specific receptors on human T lymphocytes has been
hampered by the extraordinary heterogeneity of these cells and the MHC
restrictions which govern their activation.  However, the recent
development of clonal populations of antigen specific IL-2 dependent T
cells and the availability of multiple monoclonal antibodies to T lineage
specific surface glycoproteins make it possible to overcome these
difficulties.  To this end, we will examine the capacity of various
monoclonal antibodies to indluence antigen spcific recognition and effector
function of homogeneous T cell populations in the absence of complement.
These will include monoclonal antibodies to nonpolymorphic determinants
found on all mature T lymphocytes (anti-T1, T3, T3A, T3B, T11, T12),
monoclonal antibodies to nonpolymorphic determinants selectively expressed
on subsets of T cells (anti-T4, T4A, T4B, T4C, T8, T8A, T8B, T8C, etc.) and
monoclonal antibodies to clonotypic (anti-idiotypic) determinants unique to
individual clones.  Utilizing cytotoxic T4 and T8 clones with defined MHC
class II and class I target specificities, respectively, and noncytotoxic
soluble antigen (KLH) specific clones we will define:  1) T cell surface
molecules required for the recognition phase of CTL effector function in
comparison with those employed in antigen specific recognition by
noncytolytic clones; 2) the relationship of T cell function to the novel
20KD glycoprotein defined by anti-T3 antibodies which rapidly induce its
modulation via external shedding; 3) the potential antigen binding
properties of 35S-labelled T3 molecules and any comodulating structures; 4)
the effect of clonotypic antibodies on enhancing or inhibiting function and
growth of clonotype positive and negative clones, frequency and specificity
of such clones, the relationship of structures defined by clonotypic
antibodies and nonpolymorphic structures detected with anti-T3, anti-T4 and
anti-T8, and the nature of the cellular clonal anti-clonal response; and 5)
activation antigens expressed by one or another T celll subset, the
relationship of activation structures to clonal function, and possible
genetic polymorphism of these molecules.

## Key facts

- **NIH application ID:** 3129236
- **Project number:** 5R01AI019807-05
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** ELLIS L REINHERZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $194,076
- **Award type:** 5
- **Project period:** 1983-05-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129236

## Citation

> US National Institutes of Health, RePORTER application 3129236, HUMAN T CELL ANTIGEN-RECOGNITION STRUCTURES (5R01AI019807-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129236. Licensed CC0.

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