# LIPIDS CONTROLLING STAPH AUREUS SURVIVAL IN VIVO

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 1989 · $137,991

## Abstract

This project will study the production of the fatty acid modifying
enzyme (FAME) by Staphylococcus aureus strains within
abscesses.  It will determine whether antibodies to FAME or
lipase are protective for the host.  The project will also determine
whether lipase-negative mutants of S. aureus are less able to
survive in abscesses.

Studies will be done to determine whether diabetes, steroid
administration, ether inhalation, or delayed hypersensitivity will
alter the host's ability to synthesize the bactericidal lipids in
abscesses.  Attempts will be made to isolate the substance from
Candida albicans that can increase the host's susceptibility to S.
aureus.

Efforts will be made to determine whether granulocytes or
macrophages are involved in the synthesis of the bactericidal
lipids and whether the conditions existing in inflammatory sites
are required for such synthesis.  Studies will also be conducted to
see whether the resistance to reinfection with S. aureus can be
transfered by lymphoid cells.

## Key facts

- **NIH application ID:** 3129319
- **Project number:** 5R01AI019879-05
- **Recipient organization:** OHIO STATE UNIVERSITY
- **SAM.gov UEI:** DLWBSLWAJWR1
- **Principal Investigator:** FRANK A KAPRAL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $137,991
- **Award type:** 5
- **Project period:** 1983-12-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129319

## Citation

> US National Institutes of Health, RePORTER application 3129319, LIPIDS CONTROLLING STAPH AUREUS SURVIVAL IN VIVO (5R01AI019879-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129319. Licensed CC0.

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