# IMMUNOCHEMISTRY OF TYPE II GROUP B STREPTOCOCCI

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1989 · $97,685

## Abstract

Type II group B Streptococci are a frequent cause of serious human
infections.  They are the major cause of maternal and adult group B
streptococcal infections and are second only to type III strains as a cause
of neonatal infections.  Antibodies directed against the type-specific
polysaccharides of group B streptococci are thought to play an important
role in host defense against these organisms.  However, the precise nature
of the immunological determinants against which protective antibodies are
directed is not understood.  Therefore, the complete chemical structure of
the type II polysaccharide will be determined using methylation analysis,
specific chemical degradations and 13C-N.M.R.  The exact nature of the
importance immunological determinants will be defined using various
oligosaccharide fragments as inhibitors in an ELISA employing monoclonal
antibodies to the type II polysaccharide.  In addition, the specificity of
naturally occurring antibodies to type II group B streptococci will be
examined in selected human sera from patients with known colonization
status or infection.  Two main antibody assays will be employed:  a
quantitative ELISA for measuring antibody levels, and an opsonophagocytic
assay for assessing the functional role of these antibodies.

## Key facts

- **NIH application ID:** 3129394
- **Project number:** 5R01AI019941-06
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** DAVID G PRITCHARD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $97,685
- **Award type:** 5
- **Project period:** 1983-05-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129394

## Citation

> US National Institutes of Health, RePORTER application 3129394, IMMUNOCHEMISTRY OF TYPE II GROUP B STREPTOCOCCI (5R01AI019941-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129394. Licensed CC0.

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