# STRUCTURE AND FUNCTION OF IA ANTIGENS IN MUTANT STRAINS

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 1987 · $148,525

## Abstract

Mouse strains with mutations in major histocompatibility loci have proved
extremely useful for genetic and immunologic investigations of MHC
antigens.  The first mutation (bm12) discovered in an I-A gene has already
provided several new insights into structural and functional properties of
Ia molecules, including direct genetic evidence that Ia antigens are
identical with the cell surface molecules which regulate the immune
response (the putative Ir gene products).  The further studies using bm12
mice proposed in this application should allow precise correlations between
structural changes in Ia molecules and resulting serologic and functional
changes.  The T-cell recognition and humoral responses to restricted Ia
antigenic determinants will be studied using cloned T-cell lines,
monoclonal and alloantisera, and antiidiotypic reagents.  Immune functions,
known to involve Ia, such as response to insulins of various species,
haplotype-specific suppression and skin graft enhancement, will be
investigated using bm12 mice.  Using similar approaches, newly discovered
Ia mutants (variants) will be serologically, chemically and functionally
characterized, and each of these strains should elucidate new insights into
the immunologic role of individual I region gene products.

## Key facts

- **NIH application ID:** 3129456
- **Project number:** 5R01AI019993-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **SAM.gov UEI:** L6NFUM28LQM5
- **Principal Investigator:** TED Howard HANSEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $148,525
- **Award type:** 5
- **Project period:** 1983-04-01 → 1988-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129456

## Citation

> US National Institutes of Health, RePORTER application 3129456, STRUCTURE AND FUNCTION OF IA ANTIGENS IN MUTANT STRAINS (5R01AI019993-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129456. Licensed CC0.

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