# EXPRESSION/FUNCTION OF MACROPHAGE MANNOSE RECEPTORS

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 1987 · $156,081

## Abstract

Macrophages express a cell surface receptor which binds and internalizes
glycoproteins and oligosaccharides terminating in mannose or fucose.  Liver
and blood plasma contain a mannose-binding protein (32 K) which has a
sugar-specificity similar to, if not identical, with the macrophage mannose
receptor.  The work outlined in this proposal will focus on determining the
relationship between the mannose receptor and the mannose-binding protein.
The receptor will be isolated and characterized and antibody to the
receptor will be used to undertake biosynthetic experiments.  In detail,
the presence of an intracellular precursor and secretory form of the
receptor will be explored.  The mannose receptor is regulated by the action
of macrophage activity factor and anti-inflammatory steroids.  The former
may involve an intracellular mediator, the latter appears to involve
metabolites of arachidonic acid and prostaglandins.  The modulation of the
expression of the mannose-receptor will be studied in some detail.  The
possible immunologic and physiologic functions of the mannose receptor and
mannose binding protein will be studied-specifically with respect to the
uptake of mannosylated organisms by macrophages and whether the mannose
binding protein plays some role in the adherence of certain bacteria (e.g.,
E. coli which carry mannose lectins) to the surface of cells.  A possible
role of the mannose binding protein in triggering T-lymphocytes to secrete
macrophage activation factor will be evaluated.  Finally, drug ligand
complexes will be made with high mannose oligosaccharides to target drugs
to macrophages which harbor infectious organisms such as Leishmania.

## Key facts

- **NIH application ID:** 3129484
- **Project number:** 5R01AI020015-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **SAM.gov UEI:** L6NFUM28LQM5
- **Principal Investigator:** PHILIP D STAHL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $156,081
- **Award type:** 5
- **Project period:** 1983-06-01 → 1988-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129484

## Citation

> US National Institutes of Health, RePORTER application 3129484, EXPRESSION/FUNCTION OF MACROPHAGE MANNOSE RECEPTORS (5R01AI020015-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129484. Licensed CC0.

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